PIM activity in tumours: A key node of therapy resistance

Richard J Rebello; Alisée V Huglo; Luc Furic

doi:10.1016/j.jbior.2017.10.010

PIM activity in tumours: A key node of therapy resistance

Adv Biol Regul. 2018 Jan:67:163-169. doi: 10.1016/j.jbior.2017.10.010. Epub 2017 Oct 22.

Authors

Richard J Rebello¹, Alisée V Huglo², Luc Furic³

Affiliations

¹ Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University, VIC, 3800, Australia.
² Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
³ Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University, VIC, 3800, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address: luc.furic@petermac.org.

PMID: 29111105
DOI: 10.1016/j.jbior.2017.10.010

Abstract

The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

Keywords: AKT; Breast; Cancer; MYC; PIM; Prostate; mRNA translation; mTOR.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Resistance, Neoplasm*
Humans
Neoplasms / enzymology*
Neoplasms / genetics
Neoplasms / pathology
Neoplasms / therapy
Phosphatidylinositol 3-Kinases / genetics
Phosphatidylinositol 3-Kinases / metabolism
Proto-Oncogene Proteins c-akt / genetics
Proto-Oncogene Proteins c-akt / metabolism
Proto-Oncogene Proteins c-myc / genetics
Proto-Oncogene Proteins c-myc / metabolism
Proto-Oncogene Proteins c-pim-1 / genetics
Proto-Oncogene Proteins c-pim-1 / metabolism*
Signal Transduction*

Substances

MYC protein, human
Proto-Oncogene Proteins c-myc
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-pim-1
proto-oncogene proteins pim