The TCR Takes Some Immune Responsibility

Immunity. 2017 Nov 21;47(5):803-804. doi: 10.1016/j.immuni.2017.10.018.

Abstract

In this issue of Immunity, Van Braeckel-Budimmir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.

Publication types

  • Comment

MeSH terms

  • Animals
  • Malaria*
  • Mice
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta*
  • T-Lymphocytes

Substances

  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta