ins(6;1) in a patient with congenital leukemia

R Sansone; M Sessarego; R Haupt; M L Garré; P Strigini

doi:10.1016/0165-4608(89)90069-1

ins(6;1) in a patient with congenital leukemia

Cancer Genet Cytogenet. 1989 Jan;37(1):19-22. doi: 10.1016/0165-4608(89)90069-1.

Authors

R Sansone¹, M Sessarego, R Haupt, M L Garré, P Strigini

Affiliation

¹ Center for Genetic Epidemiology and Oncogenetics, National Cancer Institute, Genova, Italy.

PMID: 2917330
DOI: 10.1016/0165-4608(89)90069-1

Abstract

Q- and C-banded karyotypes of leukemic cells of a patient with congenital acute lymphoblastic leukemia showed the karyotype: 46,XX,ins(6;1)(p21;p13p36). This rearrangement is unusual, and the breakpoints on chromosome 1 are interestingly close to known cellular oncogenes (N-ras, fgr, src-2) and to a putative antioncogene.

Publication types

Case Reports

MeSH terms

Chromosome Aberrations*
Chromosome Banding
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 6*
Female
Humans
Infant
Karyotyping
Precursor Cell Lymphoblastic Leukemia-Lymphoma / congenital
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Proto-Oncogenes