Convergent Synthesis of Digalactosyl Diacylglycerols

Org Lett. 2017 Dec 15;19(24):6482-6485. doi: 10.1021/acs.orglett.7b03043. Epub 2017 Nov 28.

Abstract

Efficient convergent chemical syntheses of digalactosyl diacylglycerols (DGDGs), which have both a galactose-galactose α(1→6)-linkage and a galactose-glycerol β-linkage along with a diacylglycerol containing various kinds of fatty acids, have been accomplished. In order to achieve a concise synthesis, we chose to use allylic protective groups as permanent protective groups. We have also achieved α- and β-selective glycosylations for the respective linkages with high yields as the key steps.

Publication types

  • Research Support, Non-U.S. Gov't