The presented results are part of a broader study of problems of alcoholism investigated within the research project on "Pathogenesis of Major Mental Diseases". The paper consists of three parts: immunovirological, psychological, and sociopsychological. Certain signs of disbalance were found in the immune system of 196 alcoholics, as compared with 363 controls, which proved reversible with the improvement of the patient's condition. This may be interpreted as an additional sign of recovery of the somatic condition of the patient. In the psychological part screening questionnaires were adapted and used in 335 inpatients and 116 outpatients. In a pilot study the pesonality characteristics of 30 obtaining alcoholics were compared with those of 37 treated alcoholics. A scale of psychic rigidity was elaborated for alcoholics (130 subjects) as compared to controls (70 subjects). The sign of psychic rip6dity was evaluated for its suitability in discriminating between alcoholics and non-addict drinkers. In the sociological part diagnostic lists were elaborated containing 195 markers reflecting different aspects of the sociopsychological profile of persons at risk and of alcohol abusers. The investigated subjects came from a factory community.