A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and aminoglycosides

J Med Microbiol. 2018 Jan;67(1):29-32. doi: 10.1099/jmm.0.000655. Epub 2017 Dec 5.

Abstract

Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiT-yaiV-ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.

Keywords: Enterobacter cloacae; hemin auxotrophic; resistance to aminoglycosides; resistance to carbapenems.

MeSH terms

  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Aztreonam / pharmacology
  • Bacterial Proteins / genetics
  • Carbapenems / pharmacology*
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Enterobacter cloacae / drug effects*
  • Enterobacter cloacae / genetics
  • Enterobacter cloacae / isolation & purification*
  • Hemin
  • Humans
  • Japan
  • Sequence Deletion / genetics

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Hemin
  • Aztreonam