In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochondrial fragmentation. The findings provide new mechanistic insights that may have therapeutic implications.
Keywords: TRPM2; calcium; cell migration; cell proliferation; lysosomal membrane permeabilisation; mitochondrial dynamics; oxidative stress; reactive oxygen species; zinc.