NUT Midline Carcinoma of the Lung in a Six-Year-Old Child

Fetal Pediatr Pathol. 2017 Dec;36(6):472-474. doi: 10.1080/15513815.2017.1392662. Epub 2017 Dec 8.

Abstract

Background: Nuclear protein of the testis (NUT) midline carcinoma is genetically defined by rearrangement of NUT or by immunohistochemical expression of NUT.

Findings: A 6-year old child had a NUT midline carcinoma of the lung. Despite aggressive therapy, the child died.

Conclusion: NUT carcinoma, which can be diagnosed immunohistochemically, remains an aggressive tumor.

Keywords: NUT midline carcinoma; immünohistochemistry; pulmonary.

Publication types

  • Case Reports

MeSH terms

  • Apoptosis
  • Carcinoma / genetics*
  • Carcinoma / therapy
  • Child
  • Diagnosis, Differential
  • Disease Progression
  • Fatal Outcome
  • Female
  • Gene Rearrangement
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / therapy
  • Necrosis
  • Nuclear Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics*

Substances

  • Nuclear Proteins
  • Oncogene Proteins, Fusion