The Elements of Translational Chemical Biology

Robert A Copeland; P Ann Boriack-Sjodin

doi:10.1016/j.chembiol.2017.11.003

The Elements of Translational Chemical Biology

Cell Chem Biol. 2018 Feb 15;25(2):128-134. doi: 10.1016/j.chembiol.2017.11.003. Epub 2017 Dec 7.

Authors

Robert A Copeland¹, P Ann Boriack-Sjodin²

Affiliations

¹ Epizyme, Inc., 400 Technology Square, Cambridge, MA 02139, USA. Electronic address: rcopeland@accenttx.com.
² Epizyme, Inc., 400 Technology Square, Cambridge, MA 02139, USA.

PMID: 29233521
DOI: 10.1016/j.chembiol.2017.11.003

Abstract

A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these molecules.

Keywords: cellular assays; chemical biology; drug discovery; target validation.

Publication types

Review

MeSH terms

Drug Discovery
Humans
Molecular Probes / chemistry
Molecular Probes / pharmacology*
Protein Processing, Post-Translational / drug effects*
Proteins / antagonists & inhibitors*
Proteins / metabolism
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*

Substances

Molecular Probes
Proteins
Small Molecule Libraries