How does obesity lead to insulin resistance?

Elife. 2017 Dec 14:6:e33298. doi: 10.7554/eLife.33298.

Abstract

Experiments on mice show that an enzyme called DNA methyltransferase 3a is involved in insulin resistance via an epigenetic mechanism.

Keywords: adipocyte; cell biology; epigenetic; glucose; insulin resistance; mouse; obesity; type 2 diabetes.

Publication types

  • Comment

MeSH terms

  • Adipocytes
  • Animals
  • DNA Methyltransferase 3A
  • Epigenesis, Genetic
  • Insulin Resistance / genetics*
  • Mice
  • Obesity / genetics