When E-cadherin is away, centrosomes can play

J Cell Biol. 2018 Jan 2;217(1):11-13. doi: 10.1083/jcb.201712033. Epub 2017 Dec 19.

Abstract

Centrosome clustering is a process frequently used by cancer cells with extra centrosomes to avoid multipolar divisions. How cell-intrinsic properties influence clustering is not entirely known. In this issue, Rhys et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704102) report an unexpected link between clustering capacity and cortical contractility through E-cadherin and DDR1 proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cadherins / metabolism*
  • Centrosome / metabolism*
  • Discoidin Domain Receptor 1 / metabolism
  • Guanine Nucleotide Exchange Factors / metabolism
  • Humans
  • Spindle Apparatus / metabolism*
  • rho GTP-Binding Proteins / metabolism
  • rhoA GTP-Binding Protein / metabolism

Substances

  • Cadherins
  • Guanine Nucleotide Exchange Factors
  • DDR1 protein, human
  • Discoidin Domain Receptor 1
  • RND3 protein, human
  • rho GTP-Binding Proteins
  • rhoA GTP-Binding Protein