Recognition of Azole-Resistant Aspergillosis by Physicians Specializing in Infectious Diseases, United States

Emerg Infect Dis. 2018 Jan;24(1):111-113. doi: 10.3201/eid2401.170971.

Abstract

Infections caused by pan-azole-resistant Aspergillus fumigatus strains have emerged in Europe and recently in the United States. Physicians specializing in infectious diseases reported observing pan-azole-resistant infections and low rates of susceptibility testing, suggesting the need for wider-scale testing.

Keywords: Aspergillus fumigatus; Cyp51A gene; antifungal; aspergillosis; azole; azole-naive; fungi; pan-azole resistance; voriconazole.

MeSH terms

  • Antifungal Agents / therapeutic use
  • Aspergillosis / drug therapy*
  • Aspergillosis / epidemiology
  • Aspergillus fumigatus / drug effects
  • Azoles / therapeutic use
  • Drug Resistance, Fungal
  • Humans
  • Infectious Disease Medicine / statistics & numerical data
  • Microbial Sensitivity Tests
  • United States / epidemiology
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Azoles
  • Voriconazole