Non-small cell lung cancer is one of the most commom malignant tumor being harmful to people's life and health. Most of the patients have developed to the last stage which not suitable for surgical indications, so radiation and chemotherapy is the main treatment strategy. In recent years, with the theory of anti-angiogenesis therapy for malignant tumors, apatinib as a promising novel medicine to treat malignant tumors, represents synergistic antitumor effects in combination with radiotherapy. The underlying mechanisms may include make blood vessel normalization, alleviating inner hypoxia, and angiogenic factors regulation. Apatinib in combination with radiotherapy may become a new and effective treatment strategy of non-small cell lung cancer.
非小细胞肺癌是危害人类生命健康的最常见的恶性肿瘤之一。大多数患者确诊时为晚期，不符合手术适应症，主要的治疗方法是放化疗联合。近年来，随着抗血管生成治疗恶性肿瘤理论的提出，阿帕替尼作为一种新型的抗肿瘤药物，与放疗联合具有协同作用。可能的机制包括使血管正常化，改善肿瘤内乏氧情况，调节促血管生成因子水平等。将阿帕替尼与放疗联合有望成为一种新的治疗策略应用于非小细胞肺癌的治疗中，提高肺癌的治疗效果。.
Keywords: Apatinib; Lung neoplasms; Radiotherapy; Tumor microenvironment.