Buccal epithelial cells display somatic, bone marrow-derived CALR mutation

Scott R Gilles; Linda B Baughn; Matthew L Schomaker; Elizabeth L Courville; Andrew C Nelson; Zohar Sachs

doi:10.1182/bloodadvances.2017012229

Buccal epithelial cells display somatic, bone marrow-derived CALR mutation

Blood Adv. 2017 Nov 16;1(25):2302-2306. doi: 10.1182/bloodadvances.2017012229. eCollection 2017 Nov 28.

Authors

Scott R Gilles¹, Linda B Baughn^{1

2}, Matthew L Schomaker¹, Elizabeth L Courville¹, Andrew C Nelson^{1

3}, Zohar Sachs^{3

4}

Affiliations

¹ Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN.
² Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
³ Masonic Cancer Center and.
⁴ Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.

Abstract

Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph⁺ CML, and no germ line CALR mutation.

Grants and funding

UL1 RR033183/RR/NCRR NIH HHS/United States