IncX3 Epidemic Plasmid Carrying blaNDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China

Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02295-17. doi: 10.1128/AAC.02295-17. Print 2018 Mar.

Abstract

Six imported pigs originating from Guangdong, Henan, and Hunan provinces in China during October 2015 to February 2017 were cultured and found to be positive for meropenem-resistant Escherichia coli The samples yielded 9 E. coli isolates of diverse sequence types carrying blaNDM-5 on IncX3 (8 isolates from 5 farms) or IncFII (1 isolate from 1 farm) plasmids. The mcr-1 gene was coharbored by 4 isolates. The IncX3 plasmids (∼46 kb) carrying blaNDM-5 were identical or nearly identical to each other.

Keywords: Enterobacteriaceae; antimicrobial resistance epidemiology; carbapenems; molecular epidemiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Husbandry
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • China / epidemiology
  • Colistin / pharmacology
  • Drug Resistance, Multiple, Bacterial
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Farms
  • Gene Expression
  • Plasmids / chemistry*
  • Plasmids / metabolism
  • Replicon
  • Swine
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • beta lactamase NDM-5, E coli
  • beta-Lactamases
  • Colistin