Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women

Eur J Clin Nutr. 2018 Oct;72(10):1458-1462. doi: 10.1038/s41430-017-0061-2. Epub 2018 Jan 18.

Abstract

Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 403 men and 373 women aged 60-81 years at baseline who participated in the follow-up study at least once. Bean, soy product and soy isoflavone intake was assessed using a 3-day dietary record at baseline. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). MMSE scores of ≤23 were used to define cognitive impairment. The relationship between bean, soy product and soy isoflavone intake and cognitive impairment was assessed using a generalized estimating equation. Multivariate-adjusted odds ratios (95% confidence intervals) for cognitive impairment with a 1 s.d. increase in total bean, total soybean and total soy isoflavone intakes were 0.48 (0.28-0.81; p = 0.006), 0.51 (0.32-0.83; p = 0.007), and 0.55 (0.32-0.93; p = 0.026), respectively, in women. Total soybean and soy isoflavone intake might decrease the risk of cognitive impairment in elderly Japanese women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian People
  • Cognition*
  • Cognitive Dysfunction / prevention & control*
  • Diet Records
  • Diet*
  • Feeding Behavior*
  • Female
  • Follow-Up Studies
  • Glycine max / chemistry*
  • Humans
  • Isoflavones / therapeutic use*
  • Japan
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio
  • Soy Foods*
  • Surveys and Questionnaires

Substances

  • Isoflavones