A prospective study of family predictors of health-related quality of life in pediatric brain tumor survivors

Pediatr Blood Cancer. 2018 Jun;65(6):e26976. doi: 10.1002/pbc.26976. Epub 2018 Jan 19.

Abstract

Background: The objective of this study was to examine prospectively the associations between family functioning at the end of tumor-directed treatment and the health-related quality of life (HRQL) of pediatric brain tumor survivors (PBTSs) approximately 9 months later.

Procedure: Thirty-five PBTS (age 6-16 years) and their mothers completed measures of family functioning and survivor HRQL within 5 months of completing tumor-directed therapy (baseline) and again approximately 9 months later (follow-up).

Results: Survivor-rated general family functioning at baseline significantly predicted mother proxy- and self-reported survivor HRQL at follow-up when controlling for survivor HRQL at baseline and relevant demographic and treatment-related variables.

Conclusions: Family functioning is a key factor contributing to survivor HRQL and should be screened throughout the course of tumor-directed treatment. Psychosocial interventions directed toward improving general family functioning may improve survivor well-being following the completion of treatment.

Keywords: brain tumor; family functioning; quality of life.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Brain Neoplasms / prevention & control*
  • Brain Neoplasms / psychology*
  • Child
  • Family Relations*
  • Female
  • Follow-Up Studies
  • Health Status
  • Humans
  • Male
  • Prognosis
  • Prospective Studies
  • Quality of Life*
  • Survival Rate
  • Survivors / psychology*