Background: Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors.
Methods: A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way.
Results: Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ²=24.908, P<0.001). MG: incidence of B2 type (58/178, 32.58%) > B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ²=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05), and whether the merger MG (χ²=0.113, P=0.736), postoperative adjuvant radiotherapy (χ²=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ²=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ²=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ²=24.695, P<0.001).
Conclusions: Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.
背景与目的 胸腺瘤常伴发重症肌无力（myasthenia gravis, MG），但是这些患者行胸腺切除的预后与MG的关系尚不明确。本研究旨在探讨影响胸腺瘤合并MG患者预后的因素。方法 回顾性分析中国胸腺瘤协作组（Chinese Alliance for Research of Thymoma, ChART）数据库1992年-2012年875例随访20年资料完整的胸腺瘤病例，分析世界卫生组织（World Health Organization, WHO）组织学分型、Masaoka分期、术后辅助治疗与MG及预后的关系。结果 胸腺瘤WHO组织学分型与MG有相关性，差异有统计学意义（χ²=24.908, P<0.001）。MG发生率为22.7%，其中B2型（58/178, 32.58%）>B3型（65/239, 27.20%）>B1型（27/132, 20.45%）>AB型（43/267, 16.10%）>A型（6/59, 10.17%），Masaoka分期与MG无相关性（χ²=1.365, P=0.714）。生存分析表明WHO分型、Masaoka分期与预后有关（P<0.05），而是否合并MG（χ²=0.113, P=0.736）、是否行胸腺扩大切除（χ²=1.548, P=0.213）、术后辅助放疗（χ²=0.380, P=0.538）与预后无相关，术后辅助化疗与差的预后相关（χ²=14.417, P<0.001）。是否行胸腺扩大切除与MG的疗效有相关性（χ²=24.695, P<0.001）。结论 胸腺瘤患者是否合并MG和是否行胸腺扩大切除与预后无相关性，胸腺扩大切除可改善MG患者的疗效。.
Keywords: Extended thymectomy; Myasthenia gravis; Prognosis; Thymoma.