Endothelial JAK2V617F does not enhance liver lesions in mice with Budd-Chiari syndrome

J Hepatol. 2018 May;68(5):1086-1087. doi: 10.1016/j.jhep.2018.01.010. Epub 2018 Jan 31.
No abstract available

Keywords: Hepatic venous outflow obstruction; Liver fibrosis; Myeloproliferative neoplasm; Portal hypertension; Splanchnic thrombosis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Budd-Chiari Syndrome / genetics*
  • Budd-Chiari Syndrome / metabolism*
  • Budd-Chiari Syndrome / pathology
  • Disease Models, Animal
  • Endothelial Cells / metabolism
  • Female
  • Humans
  • Janus Kinase 2 / genetics*
  • Janus Kinase 2 / metabolism*
  • Liver / metabolism
  • Liver / pathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation, Missense
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism

Substances

  • Recombinant Proteins
  • JAK2 protein, human
  • Janus Kinase 2