Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Blood Adv. 2018 Jan 23;2(2):85-88. doi: 10.1182/bloodadvances.2017004879.

Abstract

  1. Inhibiting contact activation of factor XI during reperfusion of acute myocardial ischemia reduces infarct size in mice.

  2. Factor XII/XI contact axis inhibition may improve the outcome of coronary artery recanalization in acute myocardial infarction.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies / immunology
  • Antibodies / pharmacology
  • Factor XI / immunology
  • Factor XI / metabolism
  • Factor XI / physiology*
  • Factor XIIa / metabolism
  • Humans
  • Inflammation / chemically induced
  • Mice
  • Myocardial Ischemia / therapy*
  • Myocardial Reperfusion Injury / etiology*
  • Protein Interaction Domains and Motifs
  • Thrombosis / chemically induced

Substances

  • Antibodies
  • Factor XI
  • Factor XIIa