Daptomycin treatment in Gram-positive vascular graft infections

Int J Infect Dis. 2018 Mar:68:69-73. doi: 10.1016/j.ijid.2018.01.009. Epub 2018 Jan 31.

Abstract

Background: Daptomycin is a bactericidal antibiotic approved for the treatment of skin and soft tissue infections and right-side endocarditis. However, there is a lack of published data outlining its usefulness in vascular graft infections (VGI). The aim of this study was to describe the clinical experience of daptomycin use in the treatment of VGI caused by Gram-positive bacteria.

Methods: This was a retrospective cohort study of patients diagnosed with VGI receiving daptomycin at a tertiary care hospital during the period January 2010 to December 2012.

Results: Of a total 1066 consecutive patients who had undergone vascular grafts (VG), 25 were diagnosed with VGI. Fifteen of these patients (11 prosthetic VG, three autologous VG, one both types) received daptomycin (median dose 6.7mg/kg/day, range 4.1-7.1mg/kg/day; median age 69 years, range 45-83 years; 80% male). The infected bypass was removed in 13 cases. The most common reason for selecting daptomycin was kidney failure (53%). The Gram-positive organisms isolated were coagulase-negative Staphylococcus (n=10), Staphylococcus aureus (n=3) (two methicillin-resistant S. aureus), Enterococcus faecium (n=2), and Enterococcus faecalis (n=1). The mean follow-up was 69 months (interquartile range 48-72 months). Ten patients (66.7%) achieved complete healing of the VGI. A recurrence of the infection was observed in 100% of patients in whom the bypass was not removed. Among patients who did not achieve complete healing, one needed a supracondylar amputation and one died as a consequence of infection. Five patients received treatment with rifampicin in addition to daptomycin and they were all cured.

Conclusions: The use of daptomycin and surgery for Gram-positive VGI was effective and well tolerated, and this may be a good alternative for the treatment of VGI in patients with peripheral arterial disease in whom renal insufficiency is common.

Keywords: Daptomycin; Gram-positive; Vascular graft infections.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Daptomycin / therapeutic use*
  • Endocarditis / drug therapy
  • Endocarditis / microbiology
  • Endocarditis / surgery
  • Enterococcus faecalis / drug effects
  • Enterococcus faecium / drug effects
  • Female
  • Follow-Up Studies
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Rifampin / therapeutic use
  • Skin Diseases, Infectious / drug therapy
  • Skin Diseases, Infectious / microbiology
  • Soft Tissue Infections / drug therapy
  • Soft Tissue Infections / microbiology
  • Staphylococcus aureus / drug effects
  • Treatment Outcome
  • Vascular Grafting*
  • Wound Healing / drug effects

Substances

  • Anti-Bacterial Agents
  • Daptomycin
  • Rifampin