FAOund the Link: Phospholipid Remodeling and Intestinal Stem Cell Growth and Tumorigenesis

Chia-Wei Cheng; Ömer H Yilmaz

doi:10.1016/j.stem.2018.01.009

FAOund the Link: Phospholipid Remodeling and Intestinal Stem Cell Growth and Tumorigenesis

Cell Stem Cell. 2018 Feb 1;22(2):141-143. doi: 10.1016/j.stem.2018.01.009.

Authors

Chia-Wei Cheng¹, Ömer H Yilmaz²

Affiliations

¹ Koch Institute for Integrative Cancer Research at MIT and Department of Biology, MIT, Cambridge, MA 02142, USA.
² Koch Institute for Integrative Cancer Research at MIT and Department of Biology, MIT, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: ohyilmaz@mit.edu.

PMID: 29395049
DOI: 10.1016/j.stem.2018.01.009

Abstract

In this issue of Cell Stem Cell, Wang et al. (2018) identify a novel link between Lpcat3-mediated phospholipid remodeling (the Lands cycle) and cholesterol biosynthesis that modulates intestinal stem cell proliferation and tumorigenesis. Notably, inhibition of cholesterol biosynthesis dampens many of the Lpcat3-deficiency-mediated effects in the intestine.

Publication types

Comment

MeSH terms

1-Acylglycerophosphocholine O-Acyltransferase*
Carcinogenesis*
Cholesterol
Humans
Intestines
Stem Cells

Substances

Cholesterol
1-Acylglycerophosphocholine O-Acyltransferase

Abstract

Publication types

MeSH terms

Substances

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