Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer

Affiliations

• ¹ Beijing SINOGENE Biotechnology Co., Ltd, Beijing 102200, China.
• ² Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China.
• ³ Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
• ⁴ College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
• ⁵ College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: 18911223116@126.com.
• ⁶ Beijing SINOGENE Biotechnology Co., Ltd, Beijing 102200, China. Electronic address: jidong-m@sinogene.com.cn.
• ⁷ Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Veterinary Medicine, Jilin University, Changchun 130062, China. Electronic address: lai_liangxue@gibh.ac.cn.