Mechanisms and biomarkers of immune quiescence in kidney transplantation

Chitranon Chan-On; Juliane M Liberto; Minnie M Sarwal

doi:10.1016/j.humimm.2018.01.016

Mechanisms and biomarkers of immune quiescence in kidney transplantation

Hum Immunol. 2018 May;79(5):356-361. doi: 10.1016/j.humimm.2018.01.016. Epub 2018 Feb 19.

Authors

Chitranon Chan-On¹, Juliane M Liberto², Minnie M Sarwal³

Affiliations

¹ Division of Nephrology, Faculty of Medicine, Department of Internal Medicine, Khon Kaen University, Khon Kaen, Thailand; Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
² Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
³ Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, United States. Electronic address: minnie.sarwal@ucsf.edu.

Abstract

This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft.

Keywords: Immune tolerance; Molecular biomarkers; Regulatory T cells; Regulatory dendritic cells; Tolerant footprint.

Publication types

Review

MeSH terms

Biomarkers / metabolism*
Dendritic Cells / immunology
Graft Rejection / immunology
Graft Survival / immunology
Humans
Immunosuppressive Agents / therapeutic use
Kidney / drug effects
Kidney / metabolism
Kidney Transplantation*
T-Lymphocytes, Regulatory / immunology
Transplantation Tolerance / immunology*

Substances

Biomarkers
Immunosuppressive Agents

Grants and funding

U01 AI113362/AI/NIAID NIH HHS/United States