Association between epicardial fat volume and fractional flow reserve: An analysis of the determination of fractional flow reserve (DeFACTO) study

Clin Imaging. 2018 Sep-Oct:51:30-34. doi: 10.1016/j.clinimag.2018.01.007. Epub 2018 Feb 2.

Abstract

Background: This study examines the relationship between epicardial fat volume (EFV) and lesion-specific ischemia by fractional flow reserve (FFR).

Methods: In a study of 173 patients (63.0 ± 8.3 years) undergoing FFR, EFV was determined using cardiac computed tomography. Relationships between EFV and FFR were assessed using multivariable linear and logistic regression.

Results: Using multivariable linear and logistic regression, no association between EFV and FFR was observed (β [SE] = -0.001 [0.003], P = 0.6, OR [95% CI]: 1.02 [0.94-1.11], P = 0.64, respectively).

Conclusion: In patients with suspected or known coronary artery disease undergoing invasive angiography, EFV was not associated with FFR.

Keywords: Coronary artery disease; Epicardial adipose tissue; Epicardial fat volume; Fractional flow reserve.

MeSH terms

  • Adipose Tissue / metabolism*
  • Aged
  • Coronary Angiography / methods
  • Coronary Artery Disease* / metabolism
  • Coronary Artery Disease* / pathology
  • Coronary Artery Disease* / physiopathology
  • Coronary Stenosis / physiopathology*
  • Female
  • Fractional Flow Reserve, Myocardial*
  • Heart / physiopathology*
  • Hemodynamics*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Pericardium / pathology*
  • Tomography, X-Ray Computed / methods