Increase of OKT4+ cells during treatment with thymostimulin in parenteral drug addicts with persistent generalized lymphadenopathy

J Clin Lab Immunol. 1986 Jun;20(2):57-61.

Abstract

Thymostimulin (TP-1), a parenterally administered calf thymus extract, has induced a significant increase of OKT4+ peripheral cells in 9 drug addicts with persistent generalized lymphadenopathy; OKT4+ lymphocytes decreased gradually after withdrawal of treatment. In a control group, a spontaneous decrease occurred in the same period of observation. A more prolonged treatment should be undertaken to assess the effectiveness of the drug on the evolution of the disease.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antibodies, Monoclonal
  • Humans
  • Immunoblastic Lymphadenopathy / blood
  • Immunoblastic Lymphadenopathy / drug therapy*
  • Male
  • Substance-Related Disorders / blood*
  • Substance-Related Disorders / drug therapy
  • T-Lymphocytes / classification
  • T-Lymphocytes / drug effects
  • T-Lymphocytes, Helper-Inducer / drug effects*
  • T-Lymphocytes, Regulatory / drug effects
  • Thymus Extracts / pharmacology
  • Thymus Extracts / therapeutic use*

Substances

  • Antibodies, Monoclonal
  • Thymus Extracts
  • thymostimulin