HIV preexposure prophylaxis: An essential, safe and effective prevention tool for sexual health

Med Mal Infect. 2018 Aug;48(5):318-326. doi: 10.1016/j.medmal.2018.01.009. Epub 2018 Feb 9.

Abstract

Preexposure prophylaxis of HIV with antiretroviral drugs is a prevention tool available in France since 2016, combined with the prevention methods already used (condoms, post-exposure treatment, rapid treatment of diagnosed HIV infections, etc.). It is targeted at populations at high risk of HIV infection, especially men who have sex with men, for whom traditional prevention methods are insufficient. We collected clinical research data, which resulted in the launch of preexposure prophylaxis in the United States and then elsewhere in the world, safety, tolerability and cost data, as well as ongoing research data (new molecules/methods of administration). We also provided an update of its use in France.

Keywords: HIV; PrEP; Prophylaxie; Prophylaxis; VIH.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / economics
  • Anti-HIV Agents / therapeutic use*
  • Bone Diseases, Metabolic / chemically induced
  • Cost-Benefit Analysis
  • Double-Blind Method
  • Drug Resistance, Viral
  • Female
  • Forecasting
  • Gastrointestinal Diseases / chemically induced
  • Global Health
  • HIV Infections / epidemiology
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • Humans
  • Kidney Diseases / chemically induced
  • Male
  • Practice Guidelines as Topic
  • Pre-Exposure Prophylaxis / economics
  • Pre-Exposure Prophylaxis / methods*
  • Randomized Controlled Trials as Topic
  • Risk-Taking
  • Sexual Behavior
  • Substance Abuse, Intravenous / epidemiology
  • World Health Organization

Substances

  • Anti-HIV Agents