Primary Central Nervous System Post-transplant Lymphoproliferative Disorder Diagnosed by Peripheral Facial Nerve Palsy

Intern Med. 2018 Jul 1;57(13):1899-1903. doi: 10.2169/internalmedicine.9613-17. Epub 2018 Feb 9.

Abstract

Although primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) causes various symptoms depending on the tumor region, there has been no previous report of PCNS-PTLD in the cerebellopontine angle that was diagnosed due to peripheral facial nerve palsy. We herein report a case involving a 62-year-old man with PCNS-PTLD in the cerebellopontine angle who was diagnosed due to peripheral facial nerve palsy. The reduction of immunosuppressive therapy, whole-brain radiotherapy, intrathecal chemotherapy, and rituximab were effective in treating this patient. Physicians should therefore be mindful that PCNS-PTLD can cause peripheral facial nerve palsy in renal transplant recipients.

Keywords: cerebellopontine angle tumor; peripheral facial nerve palsy; primary central nervous system post-transplant lymphoproliferative disorder.

Publication types

  • Case Reports

MeSH terms

  • Cerebellopontine Angle / pathology
  • Facial Nerve / pathology
  • Facial Paralysis / complications*
  • Facial Paralysis / diagnosis*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / adverse effects*
  • Lymphoproliferative Disorders / complications*
  • Lymphoproliferative Disorders / diagnosis*
  • Male
  • Middle Aged
  • Phosphoproteins
  • Rituximab / therapeutic use

Substances

  • Immunosuppressive Agents
  • PSRC1 protein, human
  • Phosphoproteins
  • Rituximab