Severe hypertriglyceridemia associated with teriflunomide in a patient with multiple sclerosis: A case report

Mult Scler. 2018 Sep;24(10):1383-1385. doi: 10.1177/1352458518761185. Epub 2018 Feb 23.

Abstract

Objective: To describe a case of severe hypertriglyceridemia in a patient receiving teriflunomide.

Methods: This is a case study.

Results: Our patient developed severe hypertriglyceridemia (>5000 mg/dL) while on teriflunomide. The drug was withdrawn. Resolution began over 3 weeks later.

Conclusion: We describe the first probable case of teriflunomide-associated severe hypertriglyceridemia in a patient with multiple sclerosis, an adverse event previously associated with leflunomide in patients with rheumatologic diseases. Clinicians should be aware of this rare but potentially dangerous adverse event.

Keywords: Teriflunomide; hypertriglyceridemia; multiple sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Crotonates / adverse effects*
  • Female
  • Humans
  • Hydroxybutyrates
  • Hypertriglyceridemia / chemically induced*
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Nitriles
  • Toluidines / adverse effects*

Substances

  • Crotonates
  • Hydroxybutyrates
  • Nitriles
  • Toluidines
  • teriflunomide