The new concept of spread through air spaces (STAS) was introduced for pulmonary adenocarcinomas in the 2015 WHO classification for lung cancer. Yet, available data demonstrate that STAS is of high prognostic impact and associated with specific clinic-pathological characteristics. This article provides a comprehensive overview of recent developments in this field.
Keywords: Airborne tumor dissemination; Lung cancer; Pulmonary adenocarcinoma; STAS; Spread through air spaces.