Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

Braz J Microbiol. 2018 Oct-Dec;49(4):785-789. doi: 10.1016/j.bjm.2017.12.010. Epub 2018 Mar 1.

Abstract

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10μg/mL).

Keywords: BVDV; Bovine viral diarrhea virus; Prostaglandin A(1); Prostaglandins; Virus-induced vacuolization.

MeSH terms

  • Animals
  • Antiviral Agents / analysis
  • Antiviral Agents / pharmacology*
  • Bovine Virus Diarrhea-Mucosal Disease / drug therapy
  • Bovine Virus Diarrhea-Mucosal Disease / virology*
  • Cattle
  • Cell Line
  • Diarrhea
  • Diarrhea Viruses, Bovine Viral / drug effects*
  • Diarrhea Viruses, Bovine Viral / genetics
  • Diarrhea Viruses, Bovine Viral / physiology
  • Prostaglandins A / analysis
  • Prostaglandins A / pharmacology*
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Prostaglandins A
  • prostaglandin A1