α-Aminoalkyl Radical Addition to Maleimides via Electron Donor-Acceptor Complexes

Org Lett. 2018 Apr 6;20(7):2051-2054. doi: 10.1021/acs.orglett.8b00597. Epub 2018 Mar 21.

Abstract

A catalyst-free, photochemical oxidative annulation reaction between dialkylanilines and maleimides to generate tetrahydroquinolines is presented. The reaction is driven by the photochemical activity of an electron donor-acceptor (EDA) complex and has a broad substrate scope with the corresponding products isolated in good to excellent yields. Photochemical characterization of the EDA complex and a mechanistic rational is provided.

Publication types

  • Research Support, Non-U.S. Gov't