Sterile Inflammation Fuels Gastric Cancer

Antonella Montinaro; Henning Walczak

doi:10.1016/j.immuni.2018.03.011

Sterile Inflammation Fuels Gastric Cancer

Immunity. 2018 Mar 20;48(3):481-483. doi: 10.1016/j.immuni.2018.03.011.

Authors

Antonella Montinaro¹, Henning Walczak²

Affiliations

¹ Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK.
² Centre for Cell Death, Cancer and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK. Electronic address: h.walczak@ucl.ac.uk.

PMID: 29562199
DOI: 10.1016/j.immuni.2018.03.011

Abstract

Constitutively activated NF-κB signaling has long been known to be oncogenic. In this issue of Immunity, O'Reilly et al. (2018) unveil a link between loss of NF-κB1, aberrant STAT1 signaling, sterile inflammation, and the increased expression of immune checkpoint molecules as cancer drivers.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinogenesis
Humans
Inflammation*
NF-kappa B*
Neoplasms
Signal Transduction

Substances

NF-kappa B

Abstract

Publication types

MeSH terms

Substances

Grants and funding