Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Sara Lovisa; Raghu Kalluri

doi:10.1016/j.molmed.2018.03.003

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Trends Mol Med. 2018 May;24(5):432-434. doi: 10.1016/j.molmed.2018.03.003. Epub 2018 Mar 21.

Authors

Sara Lovisa¹, Raghu Kalluri²

Affiliations

¹ Department of Cancer Biology, Metastasis Research Center, University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: slovisa@mdanderson.org.
² Department of Cancer Biology, Metastasis Research Center, University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: rkalluri@mdanderson.org.

PMID: 29573973
DOI: 10.1016/j.molmed.2018.03.003

Abstract

The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.

Keywords: EndMT; endothelial cells; endothelial-to-mesenchymal transition; fatty acid oxidation; metabolism.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Endothelial Cells
Endothelium*
Fatty Acids
Oxidation-Reduction
Signal Transduction*

Substances

Fatty Acids