Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis

S Deng; W Lei; G S de Hoog; L Yang; R G Vitale; H Rafati; M Seyedmousavi; A Tolooe; H van der Lee; W Liao; P E Verweij; S Seyedmousavi

doi:10.1128/AAC.00270-18

Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis

Antimicrob Agents Chemother. 2018 May 25;62(6):e00270-18. doi: 10.1128/AAC.00270-18. Print 2018 Jun.

Authors

S Deng^#¹, W Lei^#², G S de Hoog^{2

3

4

5}, L Yang³, R G Vitale⁶, H Rafati⁷, M Seyedmousavi⁷, A Tolooe⁷, H van der Lee⁵, W Liao², P E Verweij⁵, S Seyedmousavi^{8

7

9}

Affiliations

¹ Department of Medical Microbiology, People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Jiangsu, China.
² Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
³ Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
⁴ Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil.
⁵ Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
⁶ CONICET and Ramos Mejia Hospital, Parasitology Unit, Mycology Section, Buenos Aires, Argentina.
⁷ Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran.
⁸ Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands Seyedmousavi@nih.gov.
⁹ Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

^# Contributed equally.

Abstract

Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii, Cladophialophora arxii, Exophialadermatitidis, Exophialaspinifera, Fonsecaea monophora, Fonsecaea nubica, Fonsecaea pedrosoi, and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.

Keywords: amphotericin B; chromoblastomycosis; combination therapy; melanized fungi; terbinafine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology*
Antifungal Agents / pharmacology*
Ascomycota / drug effects
Chromoblastomycosis / microbiology*
Exophiala / drug effects
Microbial Sensitivity Tests
Phialophora / drug effects
Terbinafine / pharmacology*

Substances

Antifungal Agents
Amphotericin B
Terbinafine