Abstract
An intramolecular aryne Diels-Alder reaction with a furan moiety was applied to the synthesis of dihydrobenzo[ de]isochromenes as intermediates toward naphthalimides. After oxidation, this method offers an efficient approach for the synthesis of substituted naphthalimides, which showed potent cytotoxic activity against HT-29 human cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry*
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Benzene Derivatives / chemistry*
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Cycloaddition Reaction
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Furans / chemistry*
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Naphthalimides / chemical synthesis*
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Naphthalimides / chemistry*
Substances
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Antineoplastic Agents
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Benzene Derivatives
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Furans
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Naphthalimides