Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo

Viruses. 2018 Apr 3;10(4):172. doi: 10.3390/v10040172.

Abstract

Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.

Keywords: Democratic Republic of the Congo; Salmonella Typhi; bacteriophages; extended-spectrum beta lactamases (ESBL); typhoid fever.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriolysis
  • Bacteriophages / classification
  • Bacteriophages / physiology*
  • Bacteriophages / ultrastructure
  • Democratic Republic of the Congo
  • Genome, Viral
  • Humans
  • Phage Therapy
  • Phylogeny
  • Salmonella typhi / genetics*
  • Salmonella typhi / isolation & purification
  • Salmonella typhi / virology*
  • Typhoid Fever / microbiology*
  • Typhoid Fever / therapy
  • beta-Lactamases / genetics*

Substances

  • beta-lactamase CTX-M-15
  • beta-Lactamases