[Current pathogenetic data on mesangial glomerulonephritis with immunoglobulin A deposits]

Presse Med. 1988 Jan 30;17(3):115-9.
[Article in French]

Abstract

The pathogenesis of mesangial immunoglobulin A nephropathies was elucidated through the analysis of their clinical features and investigation of their biological characteristics. An alteration of the mucosal immune system is currently considered chiefly responsible for these diseases. A dysregulation of other compartments of the immune system is likely to enhance this abnormality and/or contribute to the persistence of immune complexes. Little is known, however, about the etiology of these renal diseases, and their treatment remains palliative or preventive.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Glomerular Mesangium / pathology
  • Glomerulonephritis, IGA / blood
  • Glomerulonephritis, IGA / etiology*
  • Glomerulonephritis, IGA / immunology
  • Humans
  • Immunoglobulin A / analysis
  • Lymphoid Tissue / physiopathology

Substances

  • Immunoglobulin A