Cost-Consequence Analysis Alongside a Randomised Controlled Trial of Hospital Versus Telephone Follow-Up after Treatment for Endometrial Cancer

Appl Health Econ Health Policy. 2018 Jun;16(3):415-427. doi: 10.1007/s40258-018-0378-6.

Abstract

Background: Regular outpatient follow-up programmes are usually offered to patients following treatment for gynaecological and other cancers. Despite the substantial resources involved in providing these programmes, there is evidence that routine follow-up programmes do not affect survival or the likelihood of detecting recurrence and may not meet patient needs. Alternative follow-up modalities may offer the same outcomes at lower cost. We examined the costs of using telephone-based routine follow-up of women treated for endometrial cancer undertaken by specialist gynaecology oncology nurses in comparison to routine hospital-based follow-up.

Methods: The ENDCAT trial randomised 259 women at five centres in the north west of England with a known diagnosis of Stage I endometrial cancer who had completed primary treatment on a 1:1 basis to receive either standard hospital outpatient follow-up or a telephone follow-up intervention administered by specialist nurses. A cost-consequence analysis was undertaken in which we compared costs to the health system and to individuals with the trial's co-primary outcomes of psychological morbidity and participant satisfaction with information received.

Results: Psychological morbidity, psychosocial needs, patient satisfaction and quality of life did not differ between arms. Patients randomised to telephone follow-up underwent more and longer consultations. There was no difference in total health service mean per patient costs at 6 months (mean difference £8, 95% percentile confidence interval: - £147 to £141) or 12 months (mean difference: - £77, 95% percentile confidence interval: - £334 to £154). Estimated return journey costs per patient for hospital consultations were £11.47. Productivity costs were approximately twice as high under hospital follow-up.

Conclusion: Telephone follow-up was estimated to be cost-neutral for the NHS and may free up clinic time for other patients. There was some evidence that telephone follow-up may be more efficient for patients and wider society, and is not associated with additional psychological morbidity, lower patient satisfaction or reduced quality of life.

Trial registration: ISRCTN: 75220876, prospectively registered 28 October 2011.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Cost-Benefit Analysis* / methods
  • Endometrial Neoplasms* / pathology
  • England
  • Female
  • Hospitals*
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / economics*
  • Neoplasm Recurrence, Local / prevention & control*
  • Patient Reported Outcome Measures*
  • Patient Satisfaction
  • State Medicine / economics
  • Telephone*
  • Treatment Outcome