Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1: A multi-institutional study

Ahmed R Eldesoky; Giulio Francolini; Mette S Thomsen; Esben S Yates; Tine B Nyeng; Carine Kirkove; Claus Kamby; Egil S Blix; Mette H Nielsen; Zahra Taheri-Kadkhoda; Martin Berg; Birgitte V Offersen

doi:10.1016/j.ctro.2017.01.004

Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1: A multi-institutional study

Clin Transl Radiat Oncol. 2017 Feb 6:2:36-40. doi: 10.1016/j.ctro.2017.01.004. eCollection 2017 Feb.

Authors

Ahmed R Eldesoky^{1

2}, Giulio Francolini^{1

3}, Mette S Thomsen⁴, Esben S Yates⁴, Tine B Nyeng⁴, Carine Kirkove⁵, Claus Kamby⁶, Egil S Blix⁷, Mette H Nielsen⁸, Zahra Taheri-Kadkhoda⁹, Martin Berg¹⁰, Birgitte V Offersen¹

Affiliations

¹ Department of Oncology, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark.
² Department of Clinical Oncology and Nuclear Medicine, Mansoura University, 60 Elgomhoria st, Mansoura, Egypt.
³ Department of Radiation Oncology, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Florence, Italy.
⁴ Department of Medical Physics, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark.
⁵ Department of Radiation Oncology, Catholic University of Louvain, 10 Ave Hippocrate, B-1200 Brussels, Belgium.
⁶ Department of Oncology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
⁷ Department of Oncology, University Hospital of North Norway, Sykehusvegen 38, 9019 Tromsø, Norway.
⁸ Department of Oncology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Winslowparken 19, 3, DK-5000 Odense C, Denmark.
⁹ Department of Oncology, Zealand University Hospital, Sygeshusvej 10, 4000 Roskilde, Denmark.
¹⁰ Department of Medical Physics, Hospital of Vejle, Kabbeltoft 25, 7100 Vejle, Denmark.

Abstract

The effect of Atlas-based automated segmentation (ABAS) on dose volume histogram (DVH) parameters compared to manual segmentation (MS) in loco-regional radiotherapy (RT) of early breast cancer was investigated in patients included in the Skagen Trial 1. This analysis supports implementation of ABAS in clinical practice and multi-institutional trials.

Keywords: Automated segmentation; Early breast cancer; Skagen Trial 1.