1 Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
2 Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: stephen.floor@ucsf.edu.
In this issue of Molecular Cell, Ivanov et al. (2018) demonstrate how cells sense metabolite levels and regulate production of their biosynthetic enzymes through the formation of "ribosome queues."