A Method for Isolation of Stromal Vascular Fraction Cells in a Clinically Relevant Time Frame

Methods Mol Biol. 2018:1773:11-19. doi: 10.1007/978-1-4939-7799-4_2.

Abstract

There is increasing interest in the clinical applications of adipose-derived stem cells (ASCs) and the stromal vascular fraction (SVF) based on promising preclinical data. As adipose-derived therapeutics begin to translate into the clinical setting, it is important to maintain patient safety as well as uniformity in technique. Here, we describe a method for isolation of stromal vascular fraction cells in a clinically relevant time frame. Analytical laboratory techniques are mentioned, but respective protocols are not provided here.

Keywords: ADSC; Adipose-derived stem cell; SVF; SVF isolation; Stromal vascular fraction.

MeSH terms

  • Adipose Tissue / cytology*
  • Adipose Tissue / drug effects
  • Biomarkers / analysis
  • Blood Vessels / cytology*
  • Cell Differentiation
  • Cell Fractionation / methods*
  • Cell Separation / methods*
  • Cell Survival
  • Collagenases / pharmacology
  • Flow Cytometry
  • Humans
  • Lipectomy
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / drug effects
  • Primary Cell Culture
  • Time Factors

Substances

  • Biomarkers
  • Collagenases