Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis

Marie F A Wright; Andrew Bush; Siobhan B Carr

doi:10.1016/j.prrv.2018.01.003

Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis

Paediatr Respir Rev. 2018 Jun:27:9-12. doi: 10.1016/j.prrv.2018.01.003. Epub 2018 Apr 5.

Authors

Marie F A Wright¹, Andrew Bush², Siobhan B Carr³

Affiliations

¹ Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom. Electronic address: marie.wright2@nhs.net.
² Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom; Imperial College, London, United Kingdom; National Heart and Lung Institute, London, United Kingdom.
³ Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.

PMID: 29703693
DOI: 10.1016/j.prrv.2018.01.003

Abstract

Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required.

Keywords: Cystic fibrosis; Drug hypersensitivity syndrome; Drug-related side effects and adverse reactions.

Publication types

Review

MeSH terms

Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / adverse effects
Cystic Fibrosis / drug therapy*
Drug Hypersensitivity* / diagnosis
Drug Hypersensitivity* / etiology
Drug-Related Side Effects and Adverse Reactions* / diagnosis
Drug-Related Side Effects and Adverse Reactions* / etiology
Humans
Long Term Adverse Effects* / chemically induced
Long Term Adverse Effects* / diagnosis
Patient Care Management / methods

Substances

Anti-Bacterial Agents