Testing Racemic Chiral Catalysts for Kinetic Resolution Potential

Beatriz Dominguez; Neil S Hodnett; Guy C Lloyd-Jones

doi:10.1002/1521-3773(20011119)40:22<4289::AID-ANIE4289>3.0.CO;2-4

Testing Racemic Chiral Catalysts for Kinetic Resolution Potential

Angew Chem Int Ed Engl. 2001 Nov 19;40(22):4289-4291. doi: 10.1002/1521-3773(20011119)40:22<4289::AID-ANIE4289>3.0.CO;2-4.

Authors

Beatriz Dominguez¹, Neil S Hodnett¹, Guy C Lloyd-Jones¹

Affiliation

¹ School of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, UK, Fax: (+44) 117-929-8611.

PMID: 29712108
DOI: 10.1002/1521-3773(20011119)40:22<4289::AID-ANIE4289>3.0.CO;2-4

Abstract

An even-handed approach: by use of an enantiomerically enriched substrate and study of the changes in enantiomer ratio of substrate under pseudo zero-order conditions, racemic catalysts may be employed to determine whether the enantiomerically pure catalyst would be effective for kinetic resolution of the racemic substrate (see scheme; E=CO₂ Me).

Keywords: allylation; asymmetric catalysis; kinetic resolution; palladium.