[Research on Association between Ataxia Telangiectasia Mutated(ATM)Gene Single Nucleotide Polymorphism Rs189037 C>T and Essential Hypertension]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2016 Aug;33(4):741-6.
[Article in Chinese]

Abstract

This study aimed to explore the possible association between single nucleotide polymorphism(SNP)rs189037C>T in the promoter region of ataxia telangiectasia mutated(ATM)gene and essential hypertension(EH).We performed a case-control study to collect randomly 369 hospitalized patients aged 50 years and above.They were divided into EH group(190patients)and control group(179subjects)according to the diagnostic criteria of hypertension.The SNP rs189037 genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism.The genotype frequencies of ATM gene polymorphism rs189037 for the whole sample were33.9% CC,48.0% CT,and 18.1% TT.There was no significant difference in the genotype frequency distributions of the SNP rs189037 between EH and control groups(P=0.619).After adjustment of the major confounding factors,the SNP rs189037 was still not associated with EH(P>0.05).We further analyzed data from different groups divided by genders and age respectively,and the relationship was retained(P>0.05).In addition,we found that the percentage of the TT genotype was much lower in coronary artery disease(CAD)patients than those in the CC or CT genotype(OR=0.49,95% CI=0.26~0.90,P=0.021).In conclusion,our study suggests that SNP rs189037 in the promoter of ATM gene is not associated with EH.But it is related to the incidence of CAD,and TT genotype seems to be a protective factor for CAD.

MeSH terms

  • Asian People
  • Ataxia Telangiectasia Mutated Proteins / genetics*
  • Case-Control Studies
  • Coronary Artery Disease / genetics
  • Essential Hypertension / genetics*
  • Genotype
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic*
  • Risk Factors

Substances

  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins