Timing of ECMO Initiation Impacts Survival in Influenza-Associated ARDS

Thorac Cardiovasc Surg. 2019 Apr;67(3):212-215. doi: 10.1055/s-0038-1642066. Epub 2018 May 1.

Abstract

In the past decade, extracorporeal membrane oxygenation (ECMO) has emerged as an innovative therapy for influenza-associated acute respiratory distress syndrome (ARDS). Despite its promising results, the ideal timing of ECMO initiation for these patients remains unclear. Retrospective analysis of a single institution experience with venovenous ECMO for influenza-induced ARDS was performed. Twenty-one patients were identified and categorized into early (0-2 days), standard (3-6 days), or late (more than 7 days) cannulation cohorts. Patients cannulated within 48 hours of admission had 80% survival rate at 90 days. Comparatively, the standard and late cannulation cohorts had an observed 90-day survival rate of 60 and 16.7%, respectively.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Databases, Factual
  • Extracorporeal Membrane Oxygenation* / adverse effects
  • Extracorporeal Membrane Oxygenation* / mortality
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / pathogenicity*
  • Influenza, Human / diagnosis
  • Influenza, Human / mortality
  • Influenza, Human / therapy*
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / mortality
  • Respiratory Distress Syndrome / therapy*
  • Respiratory Distress Syndrome / virology
  • Retrospective Studies
  • Risk Factors
  • Texas
  • Time Factors
  • Time-to-Treatment*
  • Treatment Outcome
  • Young Adult