Efficacy and tolerance of a miconazole-benzoyl peroxide cream combination versus a benzoyl peroxide gel in the topical treatment of acne vulgaris

Dermatologica. 1988;177(2):109-14. doi: 10.1159/000248525.

Abstract

62-65% reduction in the number of lesions was obtained in the treatment of 52 patients with acne vulgaris in this randomized single-blind study comparing a 5% benzoyl peroxide/2% miconazole cream (BPO-MCZ) with a 5% benzoyl peroxide gel (BPO). While BPO gel was equally effective in male and female patients (66 and 73% reduction of lesions), the BPO-MCZ cream was significantly more effective in the latter (50 vs. 74% mean reduction of lesions). Tolerance was significantly better with the BPO/MCZ cream preparation, particularly in females.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / therapeutic use*
  • Drug Combinations
  • Drug Tolerance
  • Female
  • Gels
  • Humans
  • Male
  • Miconazole / administration & dosage
  • Miconazole / therapeutic use*
  • Peroxides / therapeutic use*
  • Random Allocation

Substances

  • Drug Combinations
  • Gels
  • Peroxides
  • Miconazole
  • Benzoyl Peroxide