A Pilot Study Investigating the Impact of Topical Nasal Steroid Spray in Allergic Rhinitis Patients with Dry Eye

Int Arch Allergy Immunol. 2018;176(2):157-162. doi: 10.1159/000488599. Epub 2018 May 7.

Abstract

Objective: The aim of this study is to demonstrate the effect of nasal steroid treatment on intraocular pressure and dry eye in allergic rhinitis patients with dry eye.

Materials and methods: Twenty-nine patients with a diagnosis of allergic rhinitis and dry eye were included. Symptoms and findings of patients before and after nasal steroid therapy were compared.

Result: Ocular Surface Disease Index scores for dry eye symptoms showed significant improvement after nasal steroid treatment (p = 0.003). In the Schirmer test, no significant change was observed in the right or left eye (p = 0.167 and p = 0.489). For the tear film break-up time, no significant change was observed in the right or left eye (p = 0.076 and (p = 0.170). No significant change was observed in the right eye or the left eye in an intraocular pressure test (p = 0.893 and p = 0.495).

Conclusion: In our study, symptoms of dry eye with allergic rhinitis were significantly improved with nasal steroid therapy, without affecting the intraocular pressure.

Keywords: Allergic rhinitis; Dry eye; Immunoglobulin E; Nasal steroid; Schirmer test; Therapy; Treatment.

MeSH terms

  • Administration, Intranasal
  • Adolescent
  • Adrenal Cortex Hormones / administration & dosage*
  • Adult
  • Dry Eye Syndromes / drug therapy*
  • Female
  • Humans
  • Intraocular Pressure / drug effects
  • Male
  • Pilot Projects
  • Prospective Studies
  • Rhinitis, Allergic / drug therapy*
  • Young Adult

Substances

  • Adrenal Cortex Hormones