Dopamine D1 and D2 receptor selectivities of agonists and antagonists

Adv Exp Med Biol. 1988:235:55-63. doi: 10.1007/978-1-4899-2723-1_5.

Abstract

The selectivities of various dopamine agonists and antagonists for dopamine D1 and D2 receptors were obtained by comparing their relative dissociation constants for inhibiting the binding of [3H]SCH 23390 at D1 receptors (calf caudate nucleus) and at D2 receptors (pig anterior pituitary tissue). The most selective agonists were SK&F 38393 (for D1) and (+)-PHNO (for D2), while the most selective antagonists were SCH 23390 (for D1) and raclopride or eticlopride (for D2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzazepines / metabolism
  • Binding, Competitive
  • Cattle
  • Caudate Nucleus / metabolism*
  • Dopamine Antagonists*
  • Kinetics
  • Pituitary Gland, Anterior / metabolism*
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Swine

Substances

  • Benzazepines
  • Dopamine Antagonists
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2