Treatment of progressive multiple sclerosis: Challenges and promising perspectives

Rev Neurol (Paris). 2018 Jun;174(6):441-448. doi: 10.1016/j.neurol.2018.01.370. Epub 2018 May 17.

Abstract

Management of progressive multiple sclerosis (MS) is one of the main challenges of the new century. Based on our knowledge of pathophysiology, three therapeutic strategies are proposed: anti-inflammatory (ocrelizumab, siponimod…); remyelinating (opicinumab); and neuroprotective (high-dose biotin, ibudilast, simvastatin…). Nevertheless, despite recent promising positive clinical trials, new methodological approaches for therapeutic protocols with adaptable outcomes to assess progression are still needed.

Keywords: Design; Progressive multiple sclerosis; Symptomatic; Therapy; Treatment.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Disease Progression
  • Humans
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / pathology*
  • Neurology / methods
  • Neurology / standards
  • Neurology / trends
  • Pyridines / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Pyridines
  • ibudilast